Perioperative Use of Flurbiprofen Axetil on Renal Function after Transurethral Prostatectomy: A Prospective Randomized Controlled Study

Abstract

Objective. To explore the role of low-dose flurbiprofen axetil in perioperative renal protection. Methods. A total of 83 patients who underwent transurethral resection of the prostate (TURP) between August 2020 and November 2020 at the Third Xiangya Hospital of Central South University were selected, aged 60-85 years old, American Society of Anesthesia (ASA) physical status classes 1-3, BMI 18-30 kg/m2, randomly divided into the experimental group (group F, $n=42$ ) and control group (group C, $n=41$ ). 10 minutes before the operation, group F was injected with 100 mg (10 mL) flurbiprofen axetil, and group C was injected with 10 mL 0.9% saline, comparing the incidence of acute kidney injury (AKI) and changes in glomerular filtration rate (eGFR) between the two groups. Cystatin-C, Neutrophil Gelatinase-associated Lipocalin (NGAL), IL-6, and CRP were compared between the two groups at 4 time points (before surgery, 6 hours, 24 hours, and 48 hours after surgery). Results. A total of 80 cases were enrolled, 40 in group F and 40 in group C. There was no significant difference in baseline between the two groups ( $P>0.05$ ). The NGAL of group F was significantly lower than group C at 6 hours after the operation ( $367.99\pm 311.83$ vs. $243.02\pm 151.73$ , $P=0.026$ ), but there was no significant difference in NGAL and Cystatin-C at other time points ( $P>0.05$ ). And there was no significant difference in the incidence of postoperative AKI between the two groups (0% vs. 2.5%, $P=0.314$ ). Conclusion. 100 mg flurbiprofen axetil can reduce the NGAL at 6 hours after TURP, and it may have a protective effect on the kidney.