Abstract
Colon cancer is one of the most common localizations of cancer in our time. In this short presentation, I will present some aspects of the systemic therapy of advanced colon cancer. Not being able to have an exhaustive approach, I consider that emphasizing the importance of ctDNA determination in the therapeutic indication and the involvement of precision medicine in the treatment of this cancer are of first importance. Also, colon cancer is found especially at advanced ages, and I considered it necessary to emphasize
the role of geriatric consultation in these patients. This review also presents a practical aspect in chemotherapy for the elderly, namely the stability of the indication for cytostatic oxaliplatin treatment which in certain patients does not bring any benefit.