Abstract
Background and aimPhysical activity (PA) in pregnancy is important for maternal and possibly offspring health. To study the early origins of lung function we aimed to determine whether PA in the first half of pregnancy is associated with lung function in healthy 3-month-old infants.MethodsFrom the general population-based Preventing Atopic Dermatitis and Allergies in Children birth cohort recruiting infants antenatally in Norway and Sweden, all 812 infants (48.8% girls) with available tidal flow–volume measures in the awake state at 3 months of age and mid-pregnancy data on PA were included. PA was self-reported by the mothers and, based on intensity, we categorised them as active or inactive during pregnancy. Furthermore, we defined active mothers as fairly or highly active. The main outcome was a ratio of time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25. Associations were analysed by logistic regression, adjusting for maternal age, education, parity, pre-pregnancy body mass index,in uteronicotine exposure and parental atopy.ResultsThe mean±sdtPTEF/tEwas 0.391±0.08 and did not differ significantly according to maternal PA level in pregnancy. The 290 infants of inactive mothers had higher odds of havingtPTEF/tE<0.25 compared to infants of all active mothers (OR 2.07, 95% CI 1.13–3.82; p=0.019) and compared to infants (n=224) of fairly active (OR 2.83, 95% CI 1.26–7.24; p=0.018) but not highly active mothers (n=298).ConclusionBased on self-reported maternal PA in the first half of pregnancy, 3-month-old infants of inactive compared to active mothers had higher odds of a lowtPTEF/tE.
Funder
Universitetet i Oslo
Sykehuset Østfold
Insamlingsstiftelsen Cancer- och Allergifonden
Oslo University Hospital
Forte
Vårdalstiftelsen
Barnestiftelsen at Oslo University Hospital
The Samaritan Foundation for Pediatric research
SFO-V Karolinska Institutet
Stiftelsen Konung Gustaf V:s Jubileumsfond
Region Stockholm
The Regional Health Board South East
Health and Rehabilitation Norway
Konsul Th C Berghs Stiftelse
KI grants
The Pediatric Research Foundation at Astrid Lindgren Children’s Hospital
Fürst Medical Laboratory, Oslo, Norway
The Magnus Bergwall foundation
Norwegian Society of Dermatology and Venerology
Arne Ingel’s legat
Norges Forskningsråd
The Kloster foundation
Roche
Swedish Order of Freemasons Foundation Barnhuset
The Frithjof Nansen Institute
The Hesselman foundation
Thermo Fisher Scientific
The Sven Jerring Foundation
Astma- och Allergiförbundet
Hjärt-Lungfonden
Norges Astma- og Allergiforbund
Vetenskapsrådet
Svenska Läkaresällskapet
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Cited by
1 articles.
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