COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

Author:

Moon Hyo Eun123,Byun Kyunghee45,Park Hyung Woo123,Kim Jin Hyun6,Hur Jin7,Park Joong Shin8,Jun Jong Kwan8,Kim Hyo-Soo7,Paek Seung Leal1239,Kim In Keyoung1,Hwang Jae Ha1,Kim Jin Wook1,Kim Dong Gyu1,Sung Young Chul10,Koh Gou-Young11,Song Chang W12,Lee Bonghee45,Paek Sun Ha123

Affiliation:

1. Department of Neurosurgery, Seoul National University College of Medicine, Seoul 110-744, Korea

2. Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea

3. Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 110-744, Korea

4. Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Korea

5. Department of Anatomy and Cell Biology, Gachon University Medical School, Incheon 406-840, Korea

6. Clinical Research Institute, Gyeongsang National University Hospital, Jinju 660-702, Korea

7. Innovative Research Institute for Cell Therapy (IRICT), Seoul National University Hospital, Seoul 110-744, Korea

8. Department of Obstetrics & Gynecology, Seoul National University Hospital, Seoul 110-744, Korea

9. Department of Neurosurgery, Mayo Clinic, USA

10. Division of Molecular and Life Science, Integrative Bioscience & Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea

11. Laboratory for Vascular Biology and Stem Cell, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-338, Korea

12. Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, USA

Funder

Korean Government

Ministry for Health and Welfare, Republic of Korea

Korea Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry, and Fisheries

Ministry of Health & Welfare

Publisher

The Korean Society for Brain and Neural Science

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

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