Circadian Stress of Homo sapiens: New Neurophysiological, Neuroendocrine and Psychoneuroimmune Mechanisms

Abstract

Circadian stress causes dysregulation of brain Homo sapiens software followed by impairment of the cognitive and visceral brains. The body’s circadian rhythms are programmed with a system of circadian genes. Circadian clock and circadian system — are the biophysical and biochemical regulators of immune protection. Circadian synchronization system is an evolutionary software product of biocomputer for survival and preparation of the organism for expected cyclic challenges, different epigenetic orientation. Understanding the temporal relationship between stressors and stress reactions is critical to understanding the molecular foundations of the physiology and pathogenesis of the disease. Chronic stress and circadian mismatch trigger a cascade of failures in the functioning of neurophysiological, neuroendocrine, and psychoneuroimmune mechanisms. Epigenetic loading and allostatic overload reduce both the body’s overall workability and its physical, occupational, and cognitive components. Circadian stress has a pathological effect on a person, in all his age periods of life. The level of disease exposure depends on the stability of the body’s protective systems. In the works of N. P. Romanchuk, it is established that modern solution to the problem of rehabilitation of cognitive brain H. sapiens with the use, on the one hand, tools and technologies of artificial intelligence, and on the other — multidisciplinary interaction of neurophysiologist with clinical universal specialist in the field of neurology, psychiatry, psychotherapy, psychoanalysis, and geriatrics. Modern artificial intelligence technologies are capable of much, including predicting cognitive disorders and cognitive disorders, through combined and hybrid neuroimaging, next-generation sequencing, etc., with the aim of initiating timely and effective rehabilitation of brain H. sapiens. Chronotherapy and psychochronobiological strategies to protect various groups and categories of the population from the effects of circadian stress allow blocking the transition of cognitive disorders to cognitive disorders. The skin is a unique synchronized near interface of the skin-circadian system, and the condition of the skin of the face and hands is an individual indicator (biomarker) of the effect of chronic circadian stress on accelerated (premature) aging of the human body.