Dynamics of IL-1β and IL-10 Content in Blood Plasma in Experimental Animals During Modeling of a Wound Process Under Low Altitude Conditions and in the Period of Deadaptation to High Altitude

Abstract

The article presents the dynamics of the content of IL-1β and IL-10 in blood plasma in experimental animals when modeling a wounded process in low mountains and during the period of de-adaptation to high mountains while modeling a wounded process in conditions of low mountains and during a period of de-adaptation to high mountains. Animals were divided into 3 series: Series I — control series, permanently living in the conditions of Bishkek; II series — an experimental series, after a 3-day stay at the experimental high-mountain base of the KSMA named after I.K. Akhunbaev as part of the Central Scientific Research Laboratory, moved to the conditions of Bishkek with subsequent modeling and monitoring of the course of the wound process; III series - an experimental series, after a 30-day stay at the experimental high-mountain base of the KSMA named after I.K. Akhunbaev as part of the Central Scientific Research Laboratory, moved to the conditions of Bishkek, followed by modeling and monitoring the course of the wound process. Analysis of the data obtained shows that during aseptic inflammation, the opposite dynamics of the production of one of the key interleukins, with IL-1β, with a maximum concentration 12 hours after the onset of aseptic inflammation, was observed. The revealed changes in the content of cytokines during experimental aseptic inflammation determined the timely change and adequate duration of cellular reactions. In purulent inflammation, the dynamics of cytokine secretion was unidirectional, which led to a delay in all cellular phases of the inflammatory process. During the period of deadaptation after a long stay in high mountains, there is a low secretion of IL-1 and 10, associated with the depletion of protective and adaptive mechanisms.