Electrospun Nanofibers for Transdermal Drug Delivery: Current Scenarios

Abstract

Electrospinning is a commonly used approach to fabricate nanofibers of various morphologies. This method is highly effective and economically feasible, capable of producing flexible and scalable nanofibers from a wide variety of raw materials. To construct an ideal nanofiber with the desired morphological properties, electrospinning parameters involving the process, solution, and ambiance need to be fulfilled. Electrospun natural and synthetic polymeric nanofibers have recently proved to be a promising technique for drug delivery systems. Nanofiber-based drug delivery mechanisms can be utilised to transport drugs to specific locations and for a period of time to obtain the intended therapeutic outcomes. The use of electrospun nanofibers as drug carriers in biomedical applications, particularly in transdermal drug delivery systems, may be impressive in the future. Generally, in this kind of system, the active agent or drugs are delivered through the skin into the systemic circulation through a transdermal drug delivery mechanism that is distributed through the skin’s surface. Therefore, by using electrospun nanofibers as the carrier of drugs for transdermal delivery, the system can enhance the drug’s bioavailability and achieve controlled release.