Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119.-Reference-Cited by-同舟云学术

Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119.

Published:2021-11-10 Issue:4 Volume:14 Page:394-419
ISSN:1874-4710
Container-title:Current Radiopharmaceuticals
language:en
Short-container-title:CRP

Author:

Randhawa Parmissa¹,Olson Aeli P.²,Chen Shaohuang¹,Gower-Fry Kaley Lexi¹,Hoehr Cornelia³,Engle Jonathan W.²,Ramogida Caterina F.¹,Radchenko Valery³

Affiliation:

1. Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada

2. Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI, United States

3. Department of Life Sciences Division, TRIUMF, Vancouver, BC, Canada

Abstract

Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (<sup>119</sup>Sb) and mercury-197 (<sup>197</sup>Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.

Funder

United States National Institute of Health NRSA Predoctoral-NIH

Natural Sciences and Engineering Research Council of Canada-NSERC Discovery Grants

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Radiology Nuclear Medicine and imaging

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