Affiliation:
1. Pharmaceutical Chemistry Research Lab-1, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi- 221005, U.P., India
Abstract
Background:
Hydroxamic acids are a major class of organic compounds. They have a wide variety
of pharmacological actions in targeting cancers, cardiovascular diseases, HIV, Alzheimer's disease, Malaria,
Allergic diseases.
Objective:
The present review focuses on the chemistry of conventional and non-conventional routes for the
synthesis of hydroxamic acids reported till date.
Conclusion:
The hydroxamic acids are conventionally synthesized via carboxylic acid and their acid chloride
derivatives. However, some other functional groups i.e. aldehyde, amine, amide and alcohol can also be converted
to hydroxamate with ease. The solid phase synthesis techniques are also gaining importance for the synthesis
of hydroxamic acids and these pathways have opened a wide arena for the synthesis of diverse and complex
hydroxamic acids.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
18 articles.
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