Author:
Farhan H.,Albulushi A.,Taqi A.,Al-Hashim A.,Al-Saidi K.,Al-Rasadi K.,Al-Mazroui A.,Al-Zakwani I.
Abstract
Objective:
To determine the incidence and pattern of thyroid dysfunction (TD) in patients on chronic amiodarone therapy.
Methods:
A retrospective study which evaluated 59 patients who had received amiodarone therapy regularly for at least 12 months from a period of 3 years from October 2007 to October 2010. The patients were followed-up at the cardiac clinic at Sultan Qaboos University Hospital, Muscat, Oman.
Results:
The mean age of the cohort was 63 ± 13 years ranging from 27 to 98 years. Fifty-one percent (n = 30) of the patients were female. There were 11 (19%) cases of thyroid dysfunction (TD). Seven (12%) patients were hypothyroid, 3 (5%) had hyperthyroidism and 1 (2%) patient had sub-clinical hypothyroidism; no cases of sub-clinical hyperthyroidism were noted. Female gender and presence of anti-thyroid peroxidase antibodies were significantly associated with amiodarone-induced hypothyroidism (p = 0.001) while age, amiodarone dose and duration of therapy were not correlated with the development of TD (all p-values > 0.05).
Conclusion:
Amiodarone-induced thyroid dysfunction is prevalent. Hypothyroidism was more frequent and seen more in female patients and those who had positive anti-thyroid peroxidase antibodies. Initial screening and periodic monitoring of thyroid function is mandatory for all patients on amiodarone therapy.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine
Cited by
10 articles.
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