Affiliation:
1. Institute of Applied Chemistry, Hebei North University, Zhangjiakou 075000, China
2. Drug Support Center, Peoples Liberation Army General Hospital, Beijing 100853, China
Abstract
Objective:
The folate-modified graphene oxide (GO-FA), which had good stability and biocompatibility
on rat glioma cells was successfully prepared.
Methods:
The formation and composition of GO-FA were confirmed by Scanning Electron Microscope
(SEM), Transmission Electron Microscope (TEM), Fourier Transform Infrared Spectrum (FT-IR),
Raman spectra and X-ray Photoelectron Spectroscopy (XPS spectra). The cell experiment suggested
good biocompatibility of GO-FA on rat glioma cells.
Results:
The experiment of GO-FA loading with Temozolomide (TMZ) showed that the maximum
drug loading of GO-FA was 8.05 ± 0.20 mg/mg, with the drug loading rate of 89.52 ± 0.19 %. When
TMZ was released from the folate-modified graphene oxide loading with temozolomide (GO-FATMZ),
its release behavior in vitro showed strong pH dependence and sustained release property. The
growth of rat glioma cells can be effectively inhibited by GO-FA-TMZ, with the cell inhibition rate as
high as 91.72 ± 0.13 % at the concentration of 600 μg/mL and time of 72 h.
Conclusion:
According to the above experimental results, this composite carrier has potential applications
in drug delivery and cancer therapy.
Funder
Educational Department of Hebei Provincial
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology
Cited by
19 articles.
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