Medicinal plants for the treatment of neuropathic pain: A review of randomized controlled trials

Author:

Sahebkar Amirhossein12,Ahmadzade Amir Mahmoud3,Pourali Ghazaleh4,Mirheidari Seyed Behzad5,Shirazinia Matin6,Hamedi Mahdieh6,Mehri Ali7,Amirbeik Hesam6,Saghebdoust Sajjad8,Tayarani-Najaran Zahra910,Sathyapalan Thozhukat11,Forouzanfar Fatemeh12

Affiliation:

1. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Medicine, Golestan University of Medical Sciences, Golestan, Iran

6. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

7. Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

8. Department of Neurosurgery, Razavi Hospital, Mashhad, Iran

9. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

10. Medical Toxicology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

11. Academic Diabetes, Endocrinology and Metabolism, Allam Diabetes Centre Hull Royal Infirmary Anlaby Road HU3 2JZ, Hull, UK.m

12. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Abstract: Neuropathic pain is a disabling condition caused by various diseases and can profoundly impact the quality of life. Unfortunately, current treatments often do not produce complete amelioration and can be associated with potential side effects. Recently, herbal drugs have garnered more attention as an alternative or a complementary treatment. In this article, we summarized the results of randomized clinical trials to evaluate the effects of various phytomedicines on neuropathic pain. In addition, we discussed their main bioactive components and potential mechanisms of action to provide a better view of the application of herbal drugs for treating neuropathic pain.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biotechnology

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