Affiliation:
1. Department of Psychiatry, Arak University of Medical Sciences, Arak, Iran
Abstract
2:
Effective and better-tolerated agents for treatment of most of psychiatric disorders are one of the main challenges. Recently, anti-inflammatory, antioxidants and neuroprotective agents as adjuvant therapy have been shown to be able to take role against the degenerative mechanisms commonly related to psychiatric conditions. Berberine, a biological active alkaloid derived from various plants, represents many pharmacological impacts, such as antimicrobial, antidiabetic, anticancer, antioxidant and anti-inflammatory activities. This compound also protects neurons and improves the survival, growth and action of nerve cells due to its high potential for crossing the blood-brain barrier. Ample evidence reported that berberine has been associated with CNS-related disorders including Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety. Thus, in this review we aimed to indicate the effectiveness of berberine on mental disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
General Health Professions
Cited by
2 articles.
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