Affiliation:
1. MM College of Pharmacy, Department of Pharmaceutical Chemistry, Maharishi Markandeshwar (Deemed to be
University), Mullana, Ambala, Hr, 133207, India
Abstract
Abstract:
In the present-day scenario, heterocyclic derivatives have revealed the primary function of
various medicinal agents precious for humanity. Out of a diverse range of heterocycles, Styrylquinolines
scaffolds have been proved to play an essential role in a broad range of biological activities,
including anti-HIV-1, antimicrobial, anti-inflammatory, anti-Alzheimer activity with antiproliferative
effects on tumor cell lines.
Due to the immense pharmacological importance, distinct synthetic methods have been executed to
attain new drug entities from Styrylquinolines. Various schemes for synthesizing Styrylquinolines
derivatives like one-pot, ultrasound-promoted heterogeneous acid-catalysed, microwave-assisted,
solvent-free, and green synthesis were discussed in the present review. Some products of Styrylquinolines
are in clinical trials, and patents are also granted for the novel synthesis of Styrylquinolines.
According to the structure-activity relationship, replacement at the R-7 and R-8 positions is required
for various activities.
In this review, recent synthetic approaches in the medicinal chemistry of Styrylquinolines and potent
Styrylquinolines derivatives based on structural activity relationships (SAR) are outlined. Moreover,
their primary methods and modifications are also discussed.
Publisher
Bentham Science Publishers Ltd.
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