Quinoline: Synthesis to Application

Author:

Purohit Priyank12ORCID,Mittal Ravi Kumar13,Aggarwal Meenu4,Khatana Kavita5

Affiliation:

1. Department of Pharmacy, HIMT, Gautam Budha Nagar, Greater Noida, Uttar Pradesh, 201308, India

2. School of Pharmacy, Graphic Era Hill University, Clement Town Dehradun, Uttarakhand, India

3. Department of Natural Product, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar, Punjab-160062, India

4. Department of Chemistry Aggarwal College Ballabgarh, Faridabad (Haryana)- 121004, India

5. Department of Chemistry, School of Basic and Applied Sciences, SBAS, Galgotias University, Greater Noida, 67, SAS Nagar, Punjab-160062, India

Abstract

Abstract: This review aims to provide a comprehensive report on the quinoline ring with respect to its synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal, electrophile, and other reactive counterparts defines the shape of the quinoline pharmacophore, which is an important part of this report; moreover, its spectroscopic characteristics have been included herein with suitable illustration. The quinoline and its derivatives have been presented as well as the general synthetic approaches along with the new developments in the catalytic system; the relevant information is also summarized under the various separate activity classes. The synthesis of heterocyclic scaffolds has been a concern for scientists, so herein we have tried to include the synthetic parameters of quinoline with regard to the important pharmacological aspects.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery

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