Transungual Drug Delivery System for the Topical Treatment of Onychomycosis: A Review

Author:

Giri Yashwant1ORCID,Behera Amulyaratna1ORCID,Mohanty Biswaranjan2ORCID,Pattnaik Gurudutta1ORCID,Habibullah S.K.2ORCID

Affiliation:

1. School of Pharmacy and Life science, Centurion University of Technology and Management, Odisha, India

2. Department of Pharmaceutics, Institute of Pharmacy & Technology, Salipur, Odisha, India

Abstract

Abstract: Onychomycosis is an infection caused by a fungus that causes discoloration and thicken-ing of the nail layer, and it is the most common nail infection in the world. Trichophyton rubrum and Trichophyton mentagrophytes var. interdigital is the most common anthropophilic dermato-phytes that trigger it. Onychomycosis is caused by yeasts such as Candida albicans and Candida parapsilosis, as well as moulds such as Aspergillus spp. Treatment is determined by the type of nail invasion, the fungus genus, and the number of nails affected. Approaches towards conventional methods showed certain drawbacks, which emphasizes the need for alternate approaches to produce better therapeutic efficacy of a product. The present review focused on reporting an updated classi-fication of Onchyomycosis, causative organisms, factors influencing drug permeation, novel treat-ment strategies for Onychomycosis, and drug permeation enhancement methods.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science,Biomedical Engineering

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