Affiliation:
1. NSHM Knowledge Campus, Kolkata Group of Institutions, 124 BL Saha Road, Kolkata-700053, West Bengal, India
Abstract
Objective:
The presence of capsaicin in the diet has been revealed to enhance energy expenditure
and it has been used in anti-obesity therapy. The present work investigated the potential antihyperlipidemic
effect of capsaicin loaded hydrogel beads on hyperlipidemic rats. Hydrogels are three
dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological
fluids.
Methods:
Capsaicin loaded hydrogel beads were prepared by the ionotropic gelation method using
Aluminium Chloride (AlCl₃) as a cross-linking agent. The characterization of hydrogel beads was carried
out by X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Scanning Electron
Microscopic (SEM) analysis.
Results:
The surface morphology revealed that the prepared beads were spherical in shape. XRD and
DSC study of the hydrogel beads revealed that the drug was homogeneously dispersed in the hydrogel
matrix. The beads showed pH sensitive behavior and when the medium pH was changed from 1.2 to
7.4, the capsaicin release was considerably increased. 100mg/kg body weight of Triton was injected intraperitoneally
in rats to induce hyperlipidemia and it showed elevated levels of serum cholesterol and
triglyceride. Capsaicin loaded hydrogel beads were administered to normal and hyperlipidemic rats for
7 days and the prepared hydrogel beads were significantly reduced high lipid profile in comparison to
free capsaicin.
Conclusion:
The results clearly demonstrated that hydrogel beads can be used as a potential carrier for
delivery of capsaicin to reduce lipid profile.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science,Biomedical Engineering
Cited by
4 articles.
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