Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses-Reference-Cited by-同舟云学术

Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses

Published:2024-05-22 Issue: Volume:20 Page:
ISSN:1573-4110
Container-title:Current Analytical Chemistry
language:en
Short-container-title:CAC

Author:

Polanco Carlos¹²,Uversky Vladimir N.³⁴,Huberman Alberto⁵,Pimentel-Hernández Claudia⁶,Rios Castro Martha¹,Hernandez Lemus Enrique⁷,Buhse Thomas⁸,Vargas-Alarcon Gilberto⁹,Roldan Gomez Francisco J.¹⁰,Martínez-Garcia Mireya¹¹,Calvo-Leroux Corona Gabriela¹⁰,Becerra-Luna Brayans¹,Gutierrez Juárez Cynthia Karen¹,Díaz-González Juan Luciano¹²,Martinez-Memije Raul¹,Flores Ch Pedro L¹

Affiliation:

1. Department of Electromechanical Instrumentation, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City, 14080, Mexico

2. Department of Mathematics, Faculty of Sciences, Universidad Nacional Autonoma de Mexico, Mexico City, 04510, Mexico

3. Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, 33647, USA

4. Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', 142290 Pushchino, Moscow region, Russia

5. Department of Biochemistry, Instituto Nacional de Ciencias Medicas y Nutricion 'Salvador Zubiran', 14080, Mexico City, Mexico

6. Clinical Research Support Unit, Instituto Nacional de Pediatria, Mexico City, 04530, Mexico

7. Department of Computational Genomics, Instituto Nacional de Medicina Genomica, Mexico City, 14610, Mexico

8. Chemical Research Center, Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos, 62209, Mexico

9. Department of Molecular Biology and Research Direction, Instituto Nacional de Cardiología 'Ignacio Chavez', Mexico City, 14080, Mexico

10. Outpatient Clinic, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City, 14080, Mexico

11. Department of Immunology, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City 14080, Mexico

12. Secretaría Tecnica de Computo, Redes y Telecomunicaciones, Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Mexico City, 04510, Mexico

Abstract

Background: Rodents and many wild and domestic animals, including cattle, donkeys, goats, hares, ostriches, and sheep, spread the Crimean-Congo Hemorrhagic Fever Virus (CCHFV), acting as hosts for infected ticks primarily of the Hyalomma genus, which serve as vectors and reservoirs of the virus. CCHF is a severe, potentially lethal, and widespread disease, making it a serious public health issue. Environmental changes impacting rodent populations affect their global distribution and, therefore, play a role in the spread of CCHFV. Objective: This study aims togain a deeper understanding of the envelope glycoproteins expressed by the CCHFV. Methods: Multiple computational algorithms determined the Intrinsic Disorder Predisposition (PIDP), Polarity Index, and genomic profiles of each sequence of the glycoproteins. Results: When examining the Polarity Index Method Profile, 3.0v profile, and the PIDP profile, the envelope glycoproteins of the CCHFV showed different patterns. With these patterns, it was possible to identify structural and morphological similarities. Conclusion: With the PIM 3.0v profile, our computer programs were able to identify isolated CCHFV envelope glycoproteins. We believe that this research provides a deeper understanding of this virus. conclusion: Using the PIM 3.0v profile, our computer programs were able to identify isolates of the CCHFV envelope glycoproteins. We believe that this research contributes to a deeper understanding of this emerging virus.

Publisher

Bentham Science Publishers Ltd.