Regulating miRNAs Expression by Resveratrol: Novel Insights based on Molecular Mechanism and Strategies for Cancer Therapy

Author:

Keshavarzmotamed Atoosa1,Mousavi Vahide2,Masihipour Niloufar3,Rahmati Atefe4,Mousavi Dehmordi Rohollah5,Ghezelbash Behrooz6,Alimohammadi Mina7,Mafi Alireza8

Affiliation:

1. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran

2. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

3. Department of medicine, Lorestan University of Medical Science, Lorestan, Iran

4. Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | Department of Basic Sciences, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran

5. Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

6. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

7. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8. Student Research Committee, Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran | Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Abstract: Resveratrol, a polyphenolic phytoalexin found in a wide range of plants, including grapes, berries, and peanuts, is an extensively researched phytochemical with unique pharmacological capabilities and amazing potential to affect many targets in various cancers. Resveratrol's anti-cancer activities are due to its targeting of a variety of cellular and molecular mechanisms and crucial processes involved in cancer pathogenesis, such as the promotion of growth arrest, stimulation of apoptosis, suppression of cell proliferation, induction of autophagy, regulating oxidative stress and inflammation, and improving the influence of some of the other chemotherapeutic agents. MicroRNAs (miRNAs) are non-coding RNAs that modulate gene expression by degrading mRNA or inhibiting translation. MiRNAs serve critical roles in a wide range of biological activities, and disruption of miRNA expression is strongly linked to cancer progression. Recent research has shown that resveratrol has anti-proliferative and/or pro-apoptotic properties via modulating the miRNA network, which leads to the inhibition of tumor cell proliferation, the activation of apoptosis, or the increase of traditional cancer therapy effectiveness. As a result, employing resveratrol to target miRNAs will be a unique and potential anticancer approach. Here, we discuss the main advances in the modulation of miRNA expression by resveratrol, as well as the several miRNAs that may be influenced by resveratrol in different types of cancer and the significance of this natural drug as a promising strategy in cancer treatment.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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