Recent Trends and Applications of Nanostructure-based Drug Delivery in Alleviating Chronic Obstructive Pulmonary Disease (COPD)

Author:

Lokesh 1,Gulati Nisha1,Saini Annu1,Singh Sachin23,Gupta Gaurav45,MacLoughlin Ronan678,Chellappan Dinesh Kumar9,Dua Kamal310,Dureja Harish1ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India

2. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India

3. Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo-NSW 2007, Australia

4. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India

5. Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, India

6. IDA Business Park, Dangan H91 HE94, Galway, Ireland

7. School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland

8. School of Pharmacy & Pharmaceutical Sciences, Trinity College, D02 PN40 Dublin, Ireland

9. Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia

10. Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Australia

Abstract

Abstract: Chronic Obstructive Pulmonary Disease (COPD), a chronic lung disease that causes breathing difficulties and obstructs airflow from the lungs, has a significant global health burden and affects millions of people worldwide. The use of pharmaceuticals in COPD treatment is aimed to alleviate symptoms, improve lung function, prevent exacerbations, and enhance the overall quality of life for patients. Nanotechnology holds great promise to alleviate the burden of COPD. The main goal of this review is to present the full spectrum of therapeutics based on nanostructures for the treatment and management of COPD, including nanoparticles, polymeric nanoparticles, polymeric micelles, solid-lipid nanoparticles, liposomes, exosomes, nanoemulsions, nanosuspensions, and niosomes. Nanotechnology is just one of the many areas of research that may contribute to the development of more effective and personalized treatment modalities for COPD patients in the future. Future studies may be focused on enhancing the therapeutic effectiveness of nanocarriers by conducting extensive mechanistic investigations to translate current scientific knowledge for the effective management of COPD with little or no adverse effects.

Publisher

Bentham Science Publishers Ltd.

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