Rice Malt: A Solvent-Catalyst for the Synthesis of N-Substituted Pyrroles

Abstract

Aim: The synthesis of diverse N-substituted pyrroles utilizing rice malt is identified. The reaction of hexane-2,5-dione with various primary amines develops the intriguing pyrrole scaffold in moderate to good yields. Methods: The reaction was carried out at room to ambient temperature in an extremely environmentally benign condition, without the need for any additional solvents or catalysts. Results: In the synthesis of N-derivatized pyrroles, several 1 amines, both cyclic and acyclic residue, have been accomplished. Conclusion: To the best of my knowledge, no study has been reported so far based on Paal-Knorr pyrrole synthesis utilizing rice malt as a catalyst and solvent.