Affiliation:
1. Department of Chemistry, Peptide and Medicinal Chemistry Research Laboratory, Rani Channamma University, P-B,
NH-4, Belagavi, 591 156, India
Abstract
Abstract:
In recent years, heterocycle derivatives have emerged as promising molecules, and have exhibited remarkable pharmacological applications. The statistical data analysis of the presently available drug molecules in the market has revealed that more than 70% of the drug candidates are derived from the heterocycles. Various synthetic protocols have been established employing a wide range of catalysts and reaction conditions; among them, one of the catalytic areas includes nanomaterials of metals and metal oxides. Nanocatalysts play an important role in the organic transformation under green chemistry protocol, due to their recycling nature and provision of the required catalytic amount. In this review, we have provided a comprehensive summary of the re-cent progress made in the catalytic heterogeneous metal oxide NPs application, exclusively for the synthesis of heterocyclic compounds reported in the period from 2012 to 2021. Also, this review provides an inherent framework for the reader to select a suitable catalytic system of interest to synthesize desired oxygen, nitrogen, and sulphur heteroatoms containing heterocyclic scaffold with potential pharmacological activities.
Funder
UGC-MRP, University Grants Commission India
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis
Reference109 articles.
1. Fink T.; Reymond J.L.; Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery. J Chem Inf Model 2007,47(2),342-353
2. Armesto D.; Horspool W.M.; Martin N.; Ramos A.; Seoane C.; Synthesis of cyclobutenes by the novel photochemical ring contraction of 4-substituted 2-amino-3,5-dicyano-6-phenyl-4H-pyrans. J Org Chem 1989,54(13),3069-3072
3. Dabholkar V.; Badhe K.; Kurade S.; One-pot four component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using calcined Mg-Fe hydrotalcite catalyst. IJAR 2017,6,8416-8420
4. Dömling A.; Recent developments in isocyanide based multicomponent reactions in applied chemistry. Chem Rev 2006,106(1),17-89
5. Burke M.D.; Schreiber S.L.; A planning strategy for diversity-oriented synthesis. Angew Chem Int Ed 2004,43(1),46-58
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