The Therapeutic Potential of Targeting Autophagy in the Treatment of Cancer-Reference-Cited by-同舟云学术

The Therapeutic Potential of Targeting Autophagy in the Treatment of Cancer

Published:2021-10 Issue:9 Volume:21 Page:725-736
ISSN:1568-0096
Container-title:Current Cancer Drug Targets
language:en
Short-container-title:CCDT

Author:

Chaeichi-Tehrani Negin¹,Ferns Gordon A.²,Hassanian Seyed Mahdi¹,Khazaei Majid¹,Avan Amir¹

Affiliation:

1. Metabolic Syndrome Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

2. Department of Medical Education, Brighton and Sussex Medical School, Brighton, Sussex, United Kingdom

Abstract

Autophagy is a mechanism by which unwanted cellular components are degraded through a pathway that involves the lysosomes and contributes to several pathological conditions such as cancer. Gastrointestinal cancers affect the digestive organs from the esophagus to the anus and are among the most commonly diagnosed cancers globally. The modulation of autophagy using pharmacologic agents offers a great potential for cancer therapy. In this review, some commonly used compounds, together with their molecular target and the mechanism through which they stimulate or block the autophagy pathway, as well as their therapeutic benefit in treating patients with gastrointestinal cancers, are summarized.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Drug Discovery,Pharmacology,Oncology

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