Affiliation:
1. School of Biological Sciences, National Institute of Science Education and Research, HBNI, PO: Bhimpur- Padanpur, Via: Jatni, Khurdha-752050, Odisha, India
Abstract
Angiogenesis is involved in maintaining normal physiological processes like embryonic
development, wound healing, inflammation and reproduction. Pathogenesis of various diseases like
diabetic retinopathy, rheumatoid arthritis and cancer are associated with imbalanced angiogenesis.
Angiogenic stimulators and inhibitors act together for keeping angiogenic switch in balance. Recently,
miRNAs have been found to regulate various stages of angiogenesis. miRNAs are 21-23 nucleotides
long, single stranded, noncoding RNA molecules generated endogenously. miRNA's ability
to target multiple genes within a signaling pathway makes them promising target for the development
of second generation anti-angiogenesis drugs. This review was conceived with the notion of
availability of specific and comprehensive knowledge about AngiomiRs at one place. This will facilitate
the research in basic understanding and in the development of new drugs.
In this review, we have summarized the biology and therapeutic potential of the miRNAs, which are
involved in controlling angiogenesis process. In miRNA biology, we have provided the updated
summary of miRNAs in the regulation of endothelial cells, showed role of miRNAs in the signaling
pathways of angiogenesis and, discussed the gaps in complete knowledge of mechanism. We have
also provided exclusive insights regarding therapeutic potential of these miRNAs, in angiogenesis
related disorders. Additionally, we have discussed the challenges in miRNA based drug delivery and
updated the current efforts in the development of miRNA delivery methods. Though much research
is needed to discover the complete miRNA network regulating angiogenesis but once it is done, targeting
miRNA may be considered as a potential candidate for therapeutic invention against angiogenesis
related disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Drug Discovery,Pharmacology,Oncology
Cited by
215 articles.
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