Author:
Moro Maria F,Carta Mauro G,Pintus Mirra,Pintus Elisa,Melis Riccardo,Kapczinski Flavio,Vieta Eduard,Colom Francesc
Abstract
Introduction:
Abnormalities in biological rhythms (BR) may have a role in the pathophysiology of Bipolar Disorders (BD). The objective of this study is to validate the Italian version of the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), a useful tool in studying BR, and measure its accuracy in discriminating BD.
Methods:
44 outpatients with DSM-IV-TR diagnosis of BD and 38 controls balanced for sex and age were consecutively recruited. The discriminant validity of BRIAN for the screening of BD and its test re-test reliability in two evaluations were assessed.
Results:
BD patients scored 22.22±11.19 in BRIAN against 7.13±5.6 of the control group (P<0.0001). BRIAN showed a good accuracy to screen between BD non-BD at cutoff 16, a sensitivity was 68.2 and specificity was 92.5. The test-retest stability measured using Pearson’s coefficient found very high r values for each section and the total score, thus indicating a correlation at the two times of statistical significance in all measures. Cohen’s Kappa varied from 0.47 in the sociality section to 0.80 in the sleep section, with a total K mean of 0.65.
Conclusion:
The results show that the Italian version of BRIAN has good discriminant validity in detecting BD from healthy controls and shows good test-retest reliability. The study suggests the possibility of developing mixed screening tools by introducing items on dysregulation of biological rhythms to the usual measures of mood.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health,Epidemiology
Reference28 articles.
1. Carta MG, Angst J.
Epidemiological and clinical aspects of bipolar disorders: controversies or a common need to redefine the aims and methodological aspects of surveys
Clin Pract Epidemiol Ment Health
2005;
1
(1)
: 4.
2. Jones S, Benca RM.
Sleep and Biological Rhythms Abnormalities in the Pathophysiology of Bipolar Disorders in Bipolar Disorders.Chapter 10. Basic Mechanisms and Therapeutic Implications In: Jair C Soares, Allan H, Eds.
189-208 CRC Press Print ISBN: 978-0-8493-9897-1 eBook.
2007; pp.
978-1-4200-2115-8.
3. Li J, Lu WQ, Beesley S, Loudon AS, Meng QJ.
Lithium impacts on the amplitude and period of the molecular circadian clockwork
PLoS One
2012;
7
(3)
: e33292.
4. Dallaspezia S, Benedetti F.
Melatonin. circadian rhyhms.and the clock genes in bipolar disorder
Curr Psychiatry Rep
2009;
11
(6)
: 488-93.
5. Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS.
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?
J Affect Disord
2011;
132
(1-2)
: 265-9.
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