Affiliation:
1. Department of Infectious Diseases, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
2. National
Regional Infectious Diseases Center Co-constructed by National Health Commission of PRC and People's Government
of Shaanxi Province, Xi’an, China
Abstract
Abstract:
Syndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin
binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1
is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the
liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It
is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis
viruses. Previous studies have reported that SDC-1 may function as a novel and promising diagnostic
and therapeutic marker for various liver diseases, such as drug-induced liver injury, liver
fibrosis, and liver cancer. In this review, we summarize related research and highlight the mechanisms
by which SDC-1 participates in the pathogenesis of liver diseases, as well as its potential
diagnostic and therapeutic applications. This review is expected to lay the foundation for further
therapeutic strategies to target SDC-1 in liver diseases.
Funder
National Natural Science Foundation of China
Natural Science Basic Research Plan in Shaanxi Province of China
Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine