Affiliation:
1. World-Class Research Center, Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State
Medical University (Sechenov University), 119991 Moscow, Russia
Abstract
Abstract:
Transcription factors play a crucial role in providing identity to each cell population.
To maintain cell identity, it is essential to balance the expression of activator and inhibitor transcription
factors. Cell plasticity and reprogramming offer great potential for future therapeutic applications,
as they can regenerate damaged tissue. Specific niche factors can modify gene expression
and differentiate or transdifferentiate the target cell to the required fate. Ongoing research is
being carried out on the possibilities of transcription factors in regenerating neurons, with neural
stem cells (NSCs) being considered the preferred cells for generating new neurons due to their
epigenomic and transcriptome memory. NEUROD1/ASCL1, BRN2, MYTL1, and other transcription
factors can induce direct reprogramming of somatic cells, such as fibroblasts, into neurons.
However, the molecular biology of transcription factors in reprogramming and differentiation still
needs to be fully understood.
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine