Nanocrystals: A Strategic Approach for Development of Futuristic Nano-formulations and their Patenting Applicability

Abstract

Background: Nanocrystals have been found as potent, beneficial and advantageous nanocarrier systems for ameliorating the solubility, bioavailability and permeability of those drug candidates that are less water-soluble and permeable. Such an approach possesses many complications that require more research work. Objective: The main objective of the manuscript is to prepare a review on all the aspects of nanocrystals, including their advantages, recent advancements, preparation methods, recent patents, marketed products and some patents related to their characterization techniques. Methods: This manuscript has been accrued through the help of online and offline journals, books, and from some other accessible sources. This field involves new developments or inventions in the novel nanocarrier system. Results: Nanocrystals have been found to exhibit better potentiality sorting out different problems like poor drug absorption, drug-associated side effects, and targeted drug delivery. In the last decade, these nanocarriers have been opted for resolving the problem of production due to less soluble drugs. By conducting more researches, this field can be more beneficial to the health sector. Conclusion: Nanocrystals significantly to deliver several drugs via different routes like topical, oral ophthalmic, pulmonary and parenteral. This manuscript substantially shows the applicability and importance of nanocrystals as a drug delivery carrier to treat various health issues.