Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications-Reference-Cited by-同舟云学术

Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications

Published:2019-10-24 Issue:22 Volume:19 Page:1962-1980
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Garcia Denegri María Emilia¹,Bustillo Soledad¹,Gay Claudia Carolina¹,Van De Velde Andrea¹,Gomez Gabriela¹,Echeverría Silvina¹,Gauna Pereira María Del Carmen¹,Maruñak Silvana²,Nuñez Sandra²,Bogado Fabián²,Sanchez Matías²,Teibler Gladys Pamela²,Fusco Luciano¹,Leiva Laura Cristina Ana¹

Affiliation:

1. Laboratorio de Investigación en Proteínas, Instituto de Química Básica y Aplicada del Nordeste Argentino (UNNECONICET), Facultad de Ciencias Exactas y Naturales y Agrimensura, Corrientes, Argentina

2. Laboratorio de Toxicología Veterinaria dependiente de la Cátedra de Farmacología y Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, Corrientes, Argentina

Abstract

:Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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