Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers-Reference-Cited by-同舟云学术

Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

Published:2019-07-30 Issue:12 Volume:19 Page:1051-1058
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Wang Ting¹,Xu Zhuyu¹,Lu Yongping¹,Shi Jianyou¹,Liu Wenbo²,Zhang Chengchen²,Jiang Zhongliang³,Qi Baowen⁴,Bai Lan¹

Affiliation:

1. Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

2. School of Pharmacy and Life Sciences, Jiujiang University, Jiujiang, China

3. Miller School of Medicine, University of Miami, Miami, Florida, United States

4. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

Abstract

Sirtuins family is a class of NDA+ dependent protein deacetylases that play a key role in the regulation of several aspects of biological processes, such as cell cycle regulation, autophagy, immune and inflammatory response. Many studies have shown that sirtuins2 as a key player in the cancer pathway is of great significance in tumorigenesis. This review summarizes the newly discovered, in recent years, some SIRT2 inhibitors for cancer target structure, action mechanism, biological activity, substrate specificity, and signaling pathways.

Funder

Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital Foundation

Science and Technology Project of the Health Planning Committee of Sichuan

Sichuan Province Science and Technology Support Program (CN)

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

Reference46 articles.

1. Wolffe A.; Matzke M.; Epigenetics: Regulation through repression. Science [http:// dx.doi.org/10.11226/science.286.5439.481]. [PMID: 10521337].1999,286(5439),481-486

2. Chaturvedi P.; Tyagi S.C.; Epigenetic mechanisms underlying cardiac degeneration and regeneration. Int J Cardiol [http://dx.doi.org/10.1016/j.ijcard.2014.02.008]. [PMID: 24636549].2014,173(1),1-11

3. Chalkiadaki A.; Guarente L.; The multifaceted functions of sirtuins in cancer. Nat Rev Cancer [http://dx.doi.org/10.1038/nrc3985]. [PMID: 26383140].2015,15(10),608-624