Affiliation:
1. Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126, Pisa, Italy
Abstract
Angiogenesis is a key process allowing the formation of blood vessels. It is crucial for all the
tissues and organs, ensuring their function and growth. Angiogenesis is finely controlled by several
mechanisms involving complex interactions between pro- or antiangiogenic factors, and an imbalance
in this control chain may result in pathological conditions. Metals as copper, zinc and iron cover an
essential role in regulating angiogenesis, thus therapies having physiological metals as target have been
proposed. In addition, some complexes of heavier metal ions (e.g., Pt, Au, Ru) are currently used as
established or experimental anticancer agents targeting genomic or non-genomic targets. These molecules
may affect the angiogenic mechanisms determining different effects that have been only poorly
and non-systematically investigated so far. Accordingly, in this review article, we aim to recapitulate
the impact on the angiogenic process of some reference anticancer drugs, and how it is connected to the
overall pharmacological effects. In addition, we highlight how the activity of these drugs can be related
to the role of biological essential metal ions. Overall, this may allow a deeper description and understanding
of the antineoplastic activity of both approved or experimental metal complexes, providing
important insights for the synthesis of new inorganic drugs able to overcome resistance and recurrence
phenomena.
Funder
Beneficentia Stiftung Foundation
University of Pisa
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
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