A Study for Therapeutic Treatment against Parkinson’s Disease via Chou’s 5-steps Rule

Author:

Lan Jianqiang1,Liu Zhongqiang1,Liao Chenghong1,Merkler David J.2,Han Qian1,Li Jianyong3

Affiliation:

1. Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China

2. Department of Chemistry, University of South Florida, Tampa, FL, 33620, United States

3. Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, United States

Abstract

The enzyme L-DOPA decarboxylase (DDC), also called aromatic-L-amino-acid decarboxylase, catalyzes the biosynthesis of dopamine, serotonin, and trace amines. Its deficiency or perturbations in expression result in severe motor dysfunction or a range of neurodegenerative and psychiatric disorders. A DDC substrate, L-DOPA, combined with an inhibitor of the enzyme is still the most effective treatment for symptoms of Parkinson's disease. In this review, we provide an update regarding the structures, functions, and inhibitors of DDC, particularly with regards to the treatment of Parkinson's disease. This information will provide insight into the pharmacological treatment of Parkinson's disease.

Funder

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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