A Study for Therapeutic Treatment against Parkinson’s Disease via Chou’s 5-steps Rule-Reference-Cited by-同舟云学术

A Study for Therapeutic Treatment against Parkinson’s Disease via Chou’s 5-steps Rule

Published:2019-11-29 Issue:25 Volume:19 Page:2318-2333
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Lan Jianqiang¹,Liu Zhongqiang¹,Liao Chenghong¹,Merkler David J.²,Han Qian¹,Li Jianyong³

Affiliation:

1. Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China

2. Department of Chemistry, University of South Florida, Tampa, FL, 33620, United States

3. Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, United States

Abstract

The enzyme L-DOPA decarboxylase (DDC), also called aromatic-L-amino-acid decarboxylase, catalyzes the biosynthesis of dopamine, serotonin, and trace amines. Its deficiency or perturbations in expression result in severe motor dysfunction or a range of neurodegenerative and psychiatric disorders. A DDC substrate, L-DOPA, combined with an inhibitor of the enzyme is still the most effective treatment for symptoms of Parkinson's disease. In this review, we provide an update regarding the structures, functions, and inhibitors of DDC, particularly with regards to the treatment of Parkinson's disease. This information will provide insight into the pharmacological treatment of Parkinson's disease.

Funder

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

Reference187 articles.

1. Feng P-M.; Chen W.; Lin H.; Chou K-C.; iHSP-PseRAAAC: Identifying the heat shock protein families using pseudo reduced amino acid alphabet composition. Anal Biochem 2013,442(1),118-125

2. Chen W.; Feng P-M.; Deng E-Z.; Lin H.; Chou K-C.; iTIS-PseTNC: a sequence-based predictor for identifying translation initiation site in human genes using pseudo trinucleotide composition. Anal Biochem 2014,462,76-83

3. Chen W.; Feng P.; Yang H.; Ding H.; Lin H.; Chou K.C.; iRNA-AI: identifying the adenosine to inosine editing sites in RNA sequences. Oncotarget 2017,8(3),4208-4217

4. Cheng X.; Xiao X.; Chou K-C.; pLoc_bal-mGneg: Predict subcellular localization of Gram-negative bacterial proteins by quasi-balancing training dataset and general PseAAC. J Theor Biol 2018,458,92-102

5. Feng P.; Yang H.; Ding H.; Lin H.; Chen W.; Chou K-C.; iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC. Genomics 2019,111(1),96-102

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