Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds-Reference-Cited by-同舟云学术

Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds

Published:2020-11-20 Issue:28 Volume:20 Page:2578-2598
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Xu Chen¹,Fang Meng-Yuan¹,Wang Ke²,Liu Jing³,Tai Guang-Ping³,Zhang Zhao-Ting²,Ruan Ban-Feng¹

Affiliation:

1. School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China

2. Center of Tobacco Industry Development, Xuanzhou District, Xuancheng, 242000, China

3. Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei 230601, China

Abstract

Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

Funder

Anhui Province University Natural Science Research Project

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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