Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia-Reference-Cited by-同舟云学术

Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia

Published:2022-08 Issue:10 Volume:21 Page:1017-1026
ISSN:1871-5273
Container-title:CNS & Neurological Disorders - Drug Targets
language:en
Short-container-title:CNSNDDT

Author:

Irrera Natasha¹,Barbieri Maria Antonietta¹,Bagnato Gianluca¹,Ioppolo Carmelo¹,Versace Antonio Giovanni¹

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Messina, c/o AOU Policlinico G. Martino, Via C. Valeria, Gazzi, 98125, Messina, Italy

Abstract

Abstract:The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) represents a public health problem worldwide. COVID-19 triggers a maladaptive cytokine release commonly referred to as cytokine storm syndrome with increased production of proinflammatory cytokines, which also appears to contribute to chronic neuroinflammation and neurodegenerative disorders’ appearance, including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. In this context, SARS-CoV-2 might enter the central nervous system through binding with the angiotensin converting enzyme 2 receptors which are highly expressed in glial cells and neurons. For this reason, an association between COVID-19, its dependent cytokine storm, and the development and/or progression of neurodegenerative disorders might be evaluated. Therefore, the aim of this review was to assess the impact of COVID-19 on neurodegenerative disorders, focusing on the possible increased mortality risk and/or deterioration of the clinical course of pre-existing chronic neurological diseases in patients with dementia.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,General Neuroscience

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