Brief Overview of Frequently used Macrolides and Analytical Techniques for their Assessment

Abstract

Background: Macrolide antibiotics are known as versatile broad-spectrum antibiotics. Macrolides belong to the oldest group of antibacterial agents. The macrolides which are frequently used for clinical purposes are broadly categorized in three classes depending on the number of membered macrocyclic lactone ring. These three classes actually consist of 14, 15 or 16 atoms in macrocyclic lactone ring which are linked through glycosidic bonds. Erythromycin, azithromycin clarithromycin and roxithromycin are frequently used to control against bacterial infections. Methods: The quality assurance and quality controls are important tasks in the pharmaceutical industries. Consequently, to check the quality of drugs, there is a strong need to know about alternative analytical methods for the routine analysis. Many methods have been reported in the literature for the quantitative determination of erythromycin, clarithromycin, azithromycin and clarithromycin in pharmaceutical formulations and biological samples. Results: This review will cover a brief introduction of erythromycin, azithromycin, clarithromycin and roxithromycin as well as analytical techniques for their assessment. Each developed method has its own merits and demerits. Conclusion: Any accurate method could be used for the quality control and quality assurance of macrolide antibiotics according to the availability, performance and procedure of selected instrument as well as skill and expertise of the analyst.