Affiliation:
1. Department of Microbiology, Government Medical College & Hospital, Chandigarh, 160030, India
Abstract
Abstract:
Background: Typhoid fever poses a significant health challenge in low- and middleincome countries (LMiCs), impacting millions of individuals across various age groups. Its
prevalence is particularly pronounced in South Asia. Factors contributing to its transmission in
South Asia include rapid unplanned urbanization, urban-rural disparities, provision of poor water and sanitation facilities, and open defecation.
The mortality rate of typhoid fever is up to 1%, and those who survive have a protracted period
of poor health and carry an enormous financial burden. The treatment is further complicated by
the emerging antibiotic resistance leaving few treatment options in hands. This issue has become
more urgent due to the further emergence of extended drug-resistant (XDR) and multidrugresistant (MDR) typhoid strains, as well as their subsequent global spread. Fluoroquinoloneresistant Salmonella spp. is currently classified by the World Health Organization (WHO) as a
high (Priority 2) pathogen. As a result, establishing minimum inhibitory concentrations (MIC)
according to the latest guidelines may prove effective in treating typhoid fever and minimizing
the rising threat of drug resistance.
Publisher
Bentham Science Publishers Ltd.
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