Recent Advances in Understanding the Pathogenesis of Cardiovascular Diseases and Development of Treatment Modalities
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Published:2019-01-28
Issue:1
Volume:19
Page:19-32
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ISSN:1871-529X
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Container-title:Cardiovascular & Hematological Disorders-Drug Targets
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language:en
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Short-container-title:CHDDT
Author:
Mittal Rahul1, Jhaveri Vasanti M.1, Kay Sae-In Samantha2, Greer Aubrey1, Sutherland Kyle J.1, McMurry Hannah S.1, Lin Nicole1, Mittal Jeenu1, Malhotra Arul K.1, Patel Amit P.2
Affiliation:
1. Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States 2. College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida FL, United States
Abstract
Cardiovascular Diseases (CVDs) are a leading cause of morbidity and mortality
worldwide. The underlying pathology for cardiovascular disease is largely atherosclerotic in nature
and the steps include fatty streak formation, plaque progression and plaque rupture. While there is
optimal drug therapy available for patients with CVD, there are also underlying drug delivery
obstacles that must be addressed. Challenges in drug delivery warrant further studies for the
development of novel and more efficacious medical therapies. An extensive understanding of the
molecular mechanisms of disease in combination with current challenges in drug delivery serves as
a platform for the development of novel drug therapeutic targets for CVD. The objective of this
article is to review the pathogenesis of atherosclerosis, first-line medical treatment for CVD, and
key obstacles in an efficient drug delivery.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology,Molecular Medicine,General Medicine
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