Author:
Tavakoli Mohamad,Yaghini Jaber,abed Ahmad Moghare,Malekzadeh Meisam,Maleki Dina
Abstract
Background:
Methotrexate (MTX) is an immunosuppressive drug, widely used in inflammatory disturbances including rheumatoid arthritis. However, there is no consensus regarding the effect of MTX on implant osseointegration.
Objective:
The purpose of this experimental study was to investigate the effect of low dose MTX on Bone-Implant Contact (BIC) of dogs.
Methods:
Six mandibular premolar teeth (bilateral) of 8 mature dogs were extracted. After 3 months of healing, 6 implants (bone level, resorbable blast media surface) were inserted into the mandible of each dog (3 in each side). Dogs were randomly divided into a study group (receiving 2.5 mg/week MTX orally, 3 times per week for 4 weeks) and a control group each containing 4 dogs. In the 1st week, postoperative BIC was evaluated in 4 dogs, two from each group. In the 4th week, reverse torque and BIC were evaluated in the remaining 4 dogs. Data were analyzed with two-way ANOVA test for 95% confidence interval.
Results:
The reverse torque test of the 4th week, showed a satisfying osseointegration. Histopathologic evaluation revealed that the BIC was significantly higher in the control group in comparison to the MTX group in the 1st and 4th week. In addition, the BIC of both groups were significantly increased in the 4th week in comparison to the 1st week in both groups.
Conclusion:
MTX has the potential to interfere with osseointegration process.
Publisher
Bentham Science Publishers Ltd.
Reference27 articles.
1. Bosshardt DD, Chappuis V, Buser D.
Osseointegration of titanium, titanium alloy and zirconia dental implants: Current knowledge and open questions.
Periodontol 2000
2017;
73
(1)
: 22-40.
2. Trisi P, Lazzara R, Rebaudi A, Rao W, Testori T, Porter SS.
Bone-implant contact on machined and dual acid-etched surfaces after 2 months of healing in the human maxilla.
J Periodontol
2003;
74
(7)
: 945-56.
3. Tan N, Liu X, Cai Y, et al.
The influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs.
Int J Nanomedicine
2017;
12
: 5433-42.
4. Yaghini J, Moghareh Abed A, Izadi M, Birang R, Torabinia N, Tavakoli M.
Effect of short-term steroid use (prednisolone) on bone healing around implants: An experimental study on dogs OHDM
2017;
16
(2)
: 1-4.
5. Parithimarkalaignan S, Padmanabhan TV.
Osseointegration: An update.
J Indian Prosthodont Soc
2013;
13
(1)
: 2-6.
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