Affiliation:
1. Department of Pharmacy, Institute of Pharmaceutical Research, GLA University, Uttar Pradesh-281406, India
2. Department of Computer Engineering & Applications, GLA University, Uttar Pradesh-281406, India
Abstract
Abstract:
The inflammasome NLRP3 comprises a caspase recruitment domain, a pyrin domain
containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1, and an
attached nucleotide domain leucine abundant repeat. There are a wide variety of stimuli that can
activate the inflammasome NLRP3. When activated, the protein NLRP3 appoints the adapter
protein ASC. Adapter ASC protein then recruits the procaspase-1 protein, which causes the procaspase-
1 protein to be cleaved and activated, which induces cytokines. At the same time, abnormal
activation of inflammasome NLRP3 is associated with many diseases, such as diabetes,
atherosclerosis, metabolic syndrome, cardiovascular and neurodegenerative diseases. As a result,
a significant amount of effort has been put into comprehending the mechanisms behind its
activation and looking for their specific inhibitors. In this review, we primarily focused on phytochemicals
that inhibit the inflammasome NLRP3, as well as discuss the defects caused by
NLRP3 signaling. We conducted an in-depth research review by searching for relevant articles
in the Scopus, Google Scholar, and PubMed databases. By gathering information on phytochemical
inhibitors that block NLRP3 inflammasome activation, a complicated balance between inflammasome
activation or inhibition with NLRP3 as a key role was revealed in NLRP3-driven
clinical situations.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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