Author:
Akanji Musbau A.,Adeyanju Anne A.,Rotimi Damilare,Adeyemi Oluyomi S.
Abstract
Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production of nitric oxide determine its effects in biological systems. The human cells are exposed to both beneficial and harmful effects of NO. These dual effects of NO could depend on its local concentration in the cells. Additionally, the rate of synthesis, translocation, direct interaction with other molecules, and signals contribute to the biochemical and physiological effects of NO. In this review, the biochemical and physiological role of NO, particularly in health and disease as touching on cell signaling, oxidative stress, immunity, as well as cardiovascular protection amongst others, is focused on. Therefore, this review objectively discusses the dual functionality of NO in living cells.
Publisher
Bentham Science Publishers Ltd.
Subject
General Biochemistry, Genetics and Molecular Biology
Reference81 articles.
1. Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro L.
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.
J Cyclic Nucleotide Res
1979;
5
(3)
: 211-24.
2. Furchgott RF, Zawadzki JV.
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.
Nature
1980;
288
(5789)
: 373-6.
3. Dashwood MR.
Editorial: Endothelium: A target for therapeutic intervention.
Curr Vasc Pharmacol
2016;
14
(2)
: 126-9.
4. Uche OK, Ehanire VO.
Influence of nanosilver on endothelial function and vascular reactivity of isolated rabbit carotid artery.
Niger J Physiol Sci
2018;
33
(2)
: 139-44.
5. Katsuki S, Arnold W, Mittal C, Murad F.
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.
J Cyclic Nucleotide Res
1977;
3
(1)
: 23-35.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献