Affiliation:
1. Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India
Abstract
Background:
Vulvovaginal candidiasis (VVC) is a common vaginal infection caused by
candida species, affecting 70% of the women. It may occur due to the imbalance in the vaginal micro-
biodata, pregnancy, diabetes, use of antibiotics, frequent sexual activities or AIDS.
Aim:
The main aim of this review is to provide overview about different vaginal delivery systems
for the administration of antifungal agents like conventional, mucoadhesive and muco-penetrating
delivery systems.
Method:
The conventional delivery systems available have limited efficacy due to the less residence
time and adverse effects. In order to overcome these issues, a delivery system with mucoadhesive
and muco-penetrating properties is required. Mucoadhesive polymers have excellent binding
properties with mucin and thus increasing residence time. On the other hand, muco-penetrating polymers
transport the antifungal agents across the mucus layer.
Results:
This review summarizes the pathophysiology of VVC along with novel delivery systems
for the treatment of infection through mucoadhesive and muco-penetrating approaches. Surface
modifications of nano/ microparticles with mucoadhesive or muco-penetrating particles may
provide delivery systems with improved therapeutic efficacy.
Conclusion:
Based on the available data, conventional and mucoadhesive drug delivery systems
have some limitations, they still require improvement/ development for safe and effective delivery
of antifungal agents.
Publisher
Bentham Science Publishers Ltd.
Subject
General Health Professions
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