Affiliation:
1. Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2. Department of Orthopedic Surgery, Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran
Abstract
Background:
This study aimed to evaluate the serum level of human leukocyte antigen
G [HLA-G] in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)
compared to healthy controls; moreover, it attempted to assess its relationship with SLE and RA
disease activity indices.
Methods:
This descriptive study was conducted on 31 SLE patients (17 cases with a recent diagnosis
and 14 cases with a previous diagnosis), 21 RA patients (7 cases with a recent diagnosis and 14
cases with a previous diagnosis), and 18 healthy controls who visited Ghaem Hospital affiliated to
Mashhad University of Medical Sciences, Mahhad, Iran. SLE and RA activity indices were measured
and recorded. Furthemore, soluble isoforms, including shed HLA-G1 and HLA-G5, were
measured in serum samples via the ELISA method.
Results:
A comparison of the five groups showed no significant differences in the serum level of
sHLA-G. However, sHLA-G serum level was significantly higher in SLE and RA patients compared
to healthy controls (P<0.05). sHLA-G level showed no correlation with disease duration and
activity in SLE and RA patients (P>0.05). However, a strong positive correlation was observed between
the serum level of sHLA-G and 24-h urine protein in the previously diagnosed SLE group
(r=0.83, P=0.01).
Conclusion:
It seems that the serum level of sHLA-G is higher in RA and SLE patients compared
to healthy controls. Furthermore, a strong correlation was found between sHLA-G serum levels and
24-h urine protein in cases with a previous diagnosis of SLE.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献