Current State of Platelet-rich Plasma in the Treatment of Rheumatic Disease: A Retrospective Review of the Literature

Abstract

Introduction: Rheumatic diseases are a spectrum of autoimmune or inflammatory diseases that cause damage to the musculoskeletal system as well as vital organs, such as the heart, lungs, kidneys, and central nervous system. Methods: The study of rheumatic disease has made great pro-gress in the understanding and management of these conditions in the last few decades using dis-ease-modifying antirheumatic drugs and synthesized biological immunomodulating therapies. How-ever, one potential treatment that has not been well investigated in rheumatic disease is platelet-rich plasma (PRP). PRP is proposed to facilitate the healing of injured tendons and ligaments through a variety of mechanisms, including mitogenesis, angiogenesis and macrophage activation via cyto-kine release, although its exact mechanism is unclear. Result:: There has been a great deal of work in determining the exact preparation method and composition of PRP for regenerative purposes in or-thopedic surgery, sports medicine, dentistry, cardiac surgery, pediatric surgery, gynecology, urolo-gy, plastic surgery, ophthalmology, and dermatology. Despite this, there is a paucity of research on the impact of PRP on rheumatic disease Conclusion:: This study aims to summarize and evaluate the current research concerning the use of PRP in rheumatic disease.