Affiliation:
1. Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh,
India
2. Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
Abstract
Abstract:
Osteoarthritis is a degenerative joint disease that causes the cartilage and bone underneath
the joint to break down. This causes pain and stiffness. Resveratrol, a polyphenolic compound
found in various vegetables, fruits, and red wine, has been studied for its beneficial effects
on osteoarthritis. Resveratrol has been shown to target a variety of pathways, including the NF-κB,
PI3K/Akt, MAPK/ERK, and AMPK pathways. In particular, resveratrol has been studied for its potential
use in treating osteoarthritis, and it has been shown to reduce inflammation, reduce cartilage
degradation, and improve joint function. In this review, we discuss the evidence for the pharmacological
use of resveratrol in minimizing soft tissue damage associated with osteoarthritis. We summarize
the studies on how resveratrol has anti-inflammatory, anti-oxidant, and anti-apoptotic effects,
as well as effects on cartilage degradation, osteoblast and synoviocyte proliferation, and cytokine
production. We also discuss the possible mechanisms of action of resveratrol in osteoarthritis
and its potential as a therapeutic agent. Finally, we discuss the potential risks and adverse effects
of long-term resveratrol supplementation. Overall, resveratrol has been found to be a possible
treatment for osteoarthritis because of its anti-inflammatory, anti-oxidant, and anti-apoptotic properties,
and its ability to control the production of enzymes that break down cartilage, osteoblasts, and
synoviocytes. Although numerous clinical studies have demonstrated resveratrol's efficacy as an osteoarthritis
management agent, further long-term studies are needed to better understand the safety
and potential benefits of using resveratrol for osteoarthritis management.
Publisher
Bentham Science Publishers Ltd.