Stem cell treatment and cerebral palsy: A Systematic review and meta-analysis

Author:

Safari Saeid1,Motavaf Mahsa1,Dehghan Samaneh2,Ghajarzadeh Mahsa3,Ebrahimi Narges4,Zali Alireza1,Mirmosayyeb Omid5

Affiliation:

1. Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2. Stem cell and Regeneration Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran

3. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.

4. School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5. Isfahan Neurosciences Research Center, Isfahan University of medical sciences, Isfahan, Iran

Abstract

Objective: We designed this systematic review and meta-analysis to estimate the pooled efficacy and safety profile of different types of stem cells in treating patients with cerebral palsy (CP). Methods: We systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and also gray literature, including references of the included studies which were published before November 2021. We extracted data regarding the total number of participants, first author, publication year, country of origin, mean age, cell type, cell dose, cell source, method of transplantation, duration of follow-up, Gross motor function, Ashworth scale, and adverse events. Results: We found 2073 articles by literature search; after deleting duplicates, 1194 remained. Nine articles remained for meta-analysis. The SMD of GMF-66 score (after-before) treatment was 1.5 (95% CI:0.7-2.3) (I2=89.9%, P<0.001). The pooled incidence of Gastrointestinal (GI) complications after transplantation was 21% (95% CI:9-33%) (I2=56%, P=0.08). The pooled incidence of fever after transplantation was 18 % (95% CI:6-30%) (I2=87.9%, P=0.08<0.001) Conclusion: The result of this systematic review and meta-analysis show that stem cell therapy in cerebral palsy has neuroprotective properties from anti-inflammatory and anti-apoptotic activities. Stem cell therapy seems to be a promising adjunct to traditional therapies for cerebral palsy patients.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Cerebral palsy in children: A clinical practice review;Current Problems in Pediatric and Adolescent Health Care;2024-08

2. Current approach to cerebral palsy;European Journal of Paediatric Neurology;2024-07

3. A bibliometric analysis of cerebral palsy from 2003 to 2022;Frontiers in Neurology;2024-04-02

4. Knowledge mapping of spastic cerebral palsy. A bibliometric analysis of global research (2000–2022);Italian Journal of Pediatrics;2024-01-18

5. PROSPECTIVE SINGLE CENTER ANALYSIS OF OUTCOME STEM CELLS TRANSPLANTS IN PATIENTS WITH CEREBRAL PALSY;Polski Merkuriusz Lekarski;2023

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