Affiliation:
1. Department of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Abstract
:
Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent
non-hematopoietic stem cells, which display profound immunomodulatory functions and promising
therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens,
can be detrimental to nearly all body tissues. With the advance in developing a novel treatment,
including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate
the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In
this review, the immunomodulatory influence of MSCs over immune cells and the application of MSCs
transplantation in treating autoimmune diseases are highlighted.
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
41 articles.
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