Affiliation:
1. Laboratoire de Biomathématiques, Biophysique, Biochimie et Scientométrie (L3BS), de la Nature et de la Vie, Université
de Bejaia, 06000 Bejaia, Algeria
2. Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la
Vie, Université de Bejaia, 06000, Bejaia, Algeria
3. Laboratoire de Microbilogie Appliquée (LMA), Faculté des Sciences
de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia, Algeria
Abstract
Background:
Phenolic compounds, response surface methodology, optimization, apricot kernel shell, box-behnken design, central
composite design.
Objective:
This study aimed to optimize the extraction of phenolic compounds from apricot kernel
shells by different extraction techniques by studying the effects of different parameters on the extraction
efficiency, and the comparison between the Box-Behnken Design and the Central Composite
Design of the response surface methodology is done in order to have good extraction estimation.
Methods:
In this study, response surface methodology; Box-Behnken and Central Composite
Designs, was used to contrast the efficacy and investigate the principal interactions of three operating
parameters (ethanol concentration, microwave power, and extraction time), in the optimization
of phenolic compounds extraction from apricot kernel shells by microwave-assisted extraction,
ultrasonic-assisted extraction, and maceration techniques.
Results:
The results indicated that the optimal total phenolic compounds obtained with microwave
assisted extraction techniques by Box-Behnken Design was 9.30 ± 0.22 mg/g, where the ethanol
concentration, microwave power, and extraction time, were 45.85%, 370.5 W, and 11 min, respectively.
However, the optimal total phenolic compounds revealed by Central Composite Design
were 8.86 ± 0.05mg/g under ethanol concentration, microwave power, and extraction time of
51.99%, 394.37W, and 9.68min, respectively.
Conclusion:
This work proposes the best mathematical model to optimize the extraction of polyphenols
from this by-product which seems to be a possible source of phenolic compounds that can
be used in the food, cosmetic, and pharmaceutical industries.
Publisher
Bentham Science Publishers Ltd.
Subject
General Pharmacology, Toxicology and Pharmaceutics
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