Affiliation:
1. Cancer Biology Lab, Department of Biochemistry & Bioinformatics, GIS, GITAM Institute of Science, Visakhapatnam, Andhra Pradesh 530045, India
Abstract
Glioma-associated oncogene homolog 1 (GLI1) is reported as an amplified gene in human glioblastoma
cells. It is a krupple like transcription factor, belonging to the zinc finger family. The basic function of GLI1 is normal
neural development at various stages of human. The GLI1 gene was first mapped on the chromosome sub-bands
12q13.3-14.1. Further, single nucleotide polymorphism is mostly observed in translating a region of 5’ and 3’- UTR
of GLI1 gene in addition to two post-transcriptional splice variants, GLIΔN and tGLI. Additionally, it also regulates
a plethora of gene which mediates crucial cellular processes like proliferation, differentiation, oncogenesis, EMT,
and metastasis. It also regulates tumor tolerance, chemoresistance, and radioresistance. Aberrant expression of GLI1
predicts the poor survival of breast cancer patients. GLI1 is an essential mediator of the SHH signaling pathway
regulating self-renewal of stem cells, angiogenesis, and expression of FOXS1, CYR61. GLI1 mediated HH pathway
can induce apoptosis. Hence, GLI1 can be a future diagnostic, prognostic marker, and as well as a potent target of
therapeutics in breast cancer.
Funder
Indian Council of Medical Research
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology
Cited by
12 articles.
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