Affiliation:
1. Key Laboratory of Transplant Engineering and Immunology, NHFPC; Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu,China
Abstract
:
The N-3 polyunsaturated fatty acids (PUFAs) have a wide range of health benefits, including antiinflammatory
effects, improvements in lipids metabolism and promoting insulin secretion, as well as reduction of
cancer risk. Numerous studies support that N-3 PUFAs have the potentials to improve many metabolic diseases, such
as diabetes, nonalcoholic fatty liver disease and obesity, which are attributable to N-3 PUFAs mediated enhancement
of insulin secretion by pancreatic β-cells and improvements in insulin sensitivity and metabolic disorders in peripheral
insulin-sensitive tissues such as liver, muscles, and adipose tissue. In this review, we summarized the up-to-date
clinical and basic studies on the regulatory effects and molecular mechanisms of N-3 PUFAs mediated benefits on
pancreatic β-cells, adipose tissue, liver, and muscles in the context of glucose and/or lipid metabolic disorders. We
also discussed the potential factors involved in the inconsistent results from different clinical researches of N-3 PUFAs.
Funder
National Natural Science Foundation of China
Science and Technology Department of Sichuan Province
West China Hospital, Sichuan University
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology
Cited by
3 articles.
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