Affiliation:
1. The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract
Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a
member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which
governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of
GRINA has been reported in multiple diseases in human beings, such as major depressive disorder
(MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this
review, we provide a general overview of the expression and physiological function of GRINA in
the central nervous system (CNS) diseases, including stroke, depression ,epilepsy, SCZ, and Alzheimer’s
disease (AD).
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Clinical Neurology,Neurology,Pharmacology,General Medicine